75000 - Document - Document And Entity Information
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75010 - Statement - Consolidated Balance Sheets
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75020 - Statement - Consolidated Balance Sheets (Parenthetical)
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75030 - Statement - Consolidated Statements of Operations and Comprehensive Loss
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75040 - Statement - Consolidated Statements of Stockholders' Equity (audited)
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75050 - Statement - Consolidated Statements of Stockholders' Equity (Parenthetical) (audited)
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75060 - Statement - Consolidated Statements of Cash Flows
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995457 - Disclosure - Cybersecurity Risk Management, Strategy and Governance
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995467 - Disclosure - Organization, Restructuring, Going Concern and Basis of Presentation
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995477 - Disclosure - Summary of Significant Accounting Policies
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995487 - Disclosure - Fair Value Measurements
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995497 - Disclosure - Short-term Investments
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995507 - Disclosure - Restructuring and Other Related Charges
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995517 - Disclosure - Property and Equipment and Related Impairment
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995527 - Disclosure - Impairment of Right of Use Assets
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995537 - Disclosure - Accrued Expenses and Other Current Liabilities
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995547 - Disclosure - Segment Reporting
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995557 - Disclosure - Preferred and Common Stock
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995567 - Disclosure - Common Stock Warrants
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995577 - Disclosure - Stock-Based Compensation Expense
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995587 - Disclosure - Collaboration Agreement
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995597 - Disclosure - Income Taxes
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995607 - Disclosure - Leases
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995617 - Disclosure - Retirement Plan
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995627 - Disclosure - Commitment and Contingencies
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995637 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995647 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995657 - Disclosure - Fair Value Measurements (Tables)
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995667 - Disclosure - Short-term Investments (Tables)
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995677 - Disclosure - Restructuring and Other Related Charges (Tables)
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995687 - Disclosure - Property and Equipment and Related Impairment (Tables)
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995697 - Disclosure - Impairment of Right of Use Assets (Tables)
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995707 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)
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995717 - Disclosure - Segment Reporting (Tables)
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995727 - Disclosure - Preferred and Common Stock (Tables)
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995737 - Disclosure - Common Stock Warrants (Tables)
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995747 - Disclosure - Stock-Based Compensation Expense (Tables)
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995757 - Disclosure - Collaboration Agreement (Tables)
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995767 - Disclosure - Income Taxes (Tables)
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995777 - Disclosure - Leases (Tables)
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995787 - Disclosure - Retirement Plan (Tables)
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995797 - Disclosure - Organization, Restructuring, Going Concern and Basis of Presentation - Additional Information (Details)
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995807 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details)
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995817 - Disclosure - Summary of Significant Accounting Policies - Summary of Reconciliation of Cash, Cash Equivalents and Restricted Cash Reported within Balance Sheet (Details)
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995827 - Disclosure - Summary of Significant Accounting Policies - Property and Equipment (Details)
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995837 - Disclosure - Summary of Significant Accounting Policies - Summary of Basic and Diluted Net Loss per Share Attributable to Common Stockholders (Details)
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995847 - Disclosure - Summary of Significant Accounting Policies - Summary of Potentially Dilutive Securities Excluded from Calculation of Diluted Net Loss per Share (Details)
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995857 - Disclosure - Fair Value Measurements - Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)
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995867 - Disclosure - Fair Value Measurements - Additional Information (Details)
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995877 - Disclosure - Short-term Investments - Additional Information (Details)
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995887 - Disclosure - Restructuring and Other Related Charges (Additional Information) (Details)
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995897 - Disclosure - Restructuring and Other Related Charges - Summary of Restructuring Liability Activities (Details)
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995907 - Disclosure - Property and Equipment and Related Impairment - Schedule of Property and Equipment (Details)
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995917 - Disclosure - Property and Equipment and Related Impairment - Additional Information (Details)
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995927 - Disclosure - Impairment of Right of Use Assets - Additional Information (Details)
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995937 - Disclosure - Impairment of Right of Use Assets - Schedule of Fair Value Analysis of Right of Use Assets Using Discounted Cash Flow Methodology (Details)
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995947 - Disclosure - Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Details)
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995957 - Disclosure - Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Details) 2
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995967 - Disclosure - Segment Reporting - Additional Information (Details)
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995977 - Disclosure - Segment Reporting - Summary of Revenue Significant Expenses and Net Loss for Segment (Details)
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995987 - Disclosure - Preferred and Common Stock - Additional Information (Details)
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995997 - Disclosure - Preferred and Common Stock - Schedule of Assumptions Used in Black Scholes Model (Details)
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996007 - Disclosure - Preferred and Common Stock - Schedule of Common Stock Reserved for Future Issuances (Details)
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996017 - Disclosure - Common Stock Warrants - Summary of Warrants Outstanding and Exercisable (Details)
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996027 - Disclosure - Common Stock Warrants - Summary of Warrant Activity (Details)
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996037 - Disclosure - Stock-Based Compensation Expense - Additional Information (Details)
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996047 - Disclosure - Stock-Based Compensation Expense - Schedule of Stock-Based Compensation Expense (Details)
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996057 - Disclosure - Stock-Based Compensation Expense - Summary of Restricted Stock Unit Activity, Including 2024 PSUs (Details)
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996067 - Disclosure - Stock-Based Compensation Expense - Schedule of Unrecognized Stock-Based Compensation (Details)
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996077 - Disclosure - Stock-Based Compensation Expense - Schedule of Fair Value of Stock Option Estimated on Date of Grant Using Black-Scholes Option-Pricing Model or Monte Carlo Simulation in Case of Options Granted to Certain Executive Officers (Details)
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996087 - Disclosure - Stock-Based Compensation Expense - Summary of Stock Option Activity, Including Incentive Options, Under Plans (Details)
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996097 - Disclosure - Collaboration Agreement - Additional Information (Details)
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996107 - Disclosure - Collaboration Agreement - Summary of Change in the Transaction Price (Details)
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996117 - Disclosure - Collaboration Agreement - Revenue Recognized Related to Each of the Performance Obligations and the Remaining Deferred Revenue (Details)
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996127 - Disclosure - Income Taxes - Additional Information (Detail)
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996137 - Disclosure - Income Taxes (Schedule of Effective Income Tax Rate Reconciliation) (Details)
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996147 - Disclosure - Income Taxes (Schedule of Effective Income Tax Rate Reconciliation) (Details) 2
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996157 - Disclosure - Income Taxes (Schedule of Deferred Tax Assets and Liabilities) (Details)
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996167 - Disclosure - Leases - Additional Information (Details)
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996177 - Disclosure - Leases - Schedule of Components of Lease Cost (Details)
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996187 - Disclosure - Leases - Summary of Weighted-Average Remaining Lease Term and Discount Rate Related to Operating Leases (Details)
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996197 - Disclosure - Leases - Summary of Maturity of Operating Lease Liabilities (Details)
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996207 - Disclosure - Leases - Summary of Maturity of Operating Lease Liabilities (Details) 2
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996217 - Disclosure - Retirement Plan - Additional Information (Details)
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996227 - Disclosure - Commitment and Contingencies - Additional Information (Details)
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Weighted Average Grant Date Fair Value, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Proceeds from Sale of Property, Plant, and Equipment
Proceeds from Sale of Property, Plant, and Equipment, Total
Proceeds from the sale of property and equipment
Restructuring Reserve
Restructuring Reserve, Total
Restructuring reserve, ending balance
Restructuring reserve, beginning balance
Finance Lease, Liability
Finance lease liability
Finance Lease, Liability, Total
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Preferred Stock, Shares Issued
Preferred stock shares issued
Statement of Financial Position Location, Balance [Domain]
Proceeds from Issuance of Equity Gross
Proceeds from issuance of equity gross.
Proceeds from issuance of equity gross
Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]
Summary of Assets and Liabilities Measured at Fair Value on Recurring Basis
Effective Income Tax Rate Reconciliation, Tax Credit, Amount [Abstract]
Tax credits:
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Issuance of common stock and pre-funded warrants, net of issuance costs, Shares
Stock Issued During Period Shares Issuance Of Common Stock And Pre Funded Warrants Net Of Issuance Costs
Stock issued during period shares issuance of common stock and pre-funded warrants, net of issuance costs.
Issuance of common stock and pre-funded warrants, net of issuance costs, Shares
Plan Name [Axis]
Plan Name
Equity [Abstract]
Payments for tenant improvements
Payments for Tenant Improvements
Entity Current Reporting Status
Entity Current Reporting Status
Net proceeds from warrant exercises
Proceeds from Warrant Exercises
Gross proceeds for warrant exercises
US Government Agencies Debt Securities [Member]
Corporate Bonds and U.S. Government Agency Securities
Proceeds From Sale Of Common Stock warrants And Pre Funded Warrant Gross
Proceeds from sale of common stock, warrants and pre-funded warrants
Proceeds from sale of common stock warrants and pre funded warrant gross.
Operating Expenses [Abstract]
Operating expenses:
Fair Value, Inputs, Level 2 [Member]
Deferred Tax Assets, Net of Valuation Allowance
Total deferred tax assets
Commitments and Contingencies Disclosure [Text Block]
Commitment and Contingencies
Common Stock, Shares Authorized
Common stock shares authorized
Massachusetts
MASSACHUSETTS
Option Indexed to Issuer's Equity, Type [Axis]
Option Indexed to Issuer's Equity, Type
Modification of Lease Agreement
Modification of Lease Agreement
Modification of lease agreement
Document Fiscal Period Focus
Document Fiscal Period Focus
Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration]
Entity Shell Company
Entity Shell Company
SEC Schedule, 12-09, Valuation Allowances and Reserves Type [Axis]
Segment Reporting, Policy [Policy Text Block]
Segment Reporting
Cash and Cash Equivalent
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Lessee Operating Lease Liability Payments Due After Year Four
Lessee operating lease liability payments due after year four.
Thereafter
Organization and basis of presentation.
Organization And Basis Of Presentation [Table]
Organization And Basis Of Presentation [Table]
Exercise Price Of Underlying Shares
Exercise price of underlying shares.
Exercise price of underlying shares.
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common Stock, Shares, Issued
Common stock shares issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Impairment of right of use asset
Impairment of right of use asset.
Impairment of right-of-use assets
Impairment of ROU asset
Statement [Table]
Statement [Table]
Restricted Cash, Noncurrent
Restricted cash
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Right of Use Asset in Exchange for Lease Liability
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average fair value of options granted to employees, directors and non-employees
Development activities performance obligation.
Development Activities Performance Obligation [Member]
Development Activities Performance Obligation
Statement [Line Items]
Statement [Line Items]
Revenue from Contract with Customer [Policy Text Block]
Revenue Recognition
Stock warrants
Warrant [Member]
Purchase Warrants
Entity Filer Category
Entity Filer Category
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Product Development and manufacturing costs [Member]
Product development and manufacturing costs.
Product Development and Manufacturing Costs
Liabilities and Equity
Total liabilities and stockholders' (deficit) equity
Payables and Accruals [Abstract]
Other assets policy.
Other Assets [Policy Text Block]
Other Assets
Share-Based Payment Arrangement, Nonvested Award, Cost [Table Text Block]
Schedule of Unrecognized Stock-Based Compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercisable at December 31, 2024
Restructuring Type [Axis]
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Severance Costs
Severance costs
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase in valuation allowance
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Financing costs
Financing costs.
Financing costs
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Restructuring and Related Costs [Table Text Block]
Summary of Restructuring Liability Activities
Cash and Cash Equivalents, Fair Value Disclosure
Cash equivalents
Asset Impairment Charge [Line Item]
Asset impairment charge.
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Less: valuation allowance
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Income tax computed at federal statutory tax rate, percentage
Shares Issued, Price Per Share
Shares issued and sold, public offering price
Shares issued and sold, public offering price
Schedule Of Discounted Cash Flow methodology Range Of Assumptions [Table Text Block]
Schedule of discounted cash flow methodology range of assumptions.
Schedule of Fair Value Analysis of Right of Use Assets Using Discounted Cash Flow Methodology
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Effective Income Tax Rate Reconciliation, Percent
Total, percentage
Stock Options
Investment Income, Interest
Interest income
Proceeds From Issuance Of Stock Debt Securities Warrants And Units Net Of Issuance Costs
Proceeds from issuance of Stock, debt securities, warrants and units, net of issuance costs.
Proceeds from issuance of Stock, debt securities, warrants and units, net of issuance costs
Income Tax Jurisdiction [Axis]
Proceeds to be occured from future issuance of common stock,.
Proceeds To Be Occured From Future Issuance Of Common Stock
Proceeds to be occured from future issuance of common stock
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Restricted Cash
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Numerator:
Revenue Description
Revenue description.
Revenue description
Significant Change in Unrecognized Tax Benefits is Reasonably Possible, Amount of Unrecorded Benefit
Significant change in unrecognized tax benefits is reasonably possible, amount of unrecorded benefit
Retention Costs
Retention costs.
Retention costs
Additional Paid in Capital, Common Stock
Additional paid-in capital
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Schedule of Cash and Cash Equivalents [Table Text Block]
Summary of Reconciliation of Cash, Cash Equivalents and Restricted Cash Reported within Balance Sheet
Stock issued during period, shares, Exercise of common stock warrants
Stock issued during period, shares, Exercise of common stock warrants.
Issuance of common stock upon exercise of common stock warrants, Shares
Shares, Granted
Number of shares granted
Options to purchase
Class of warrant or right, expiration description
Class of warrant or right, expiration description.
Inducement Award Plan
Inducement Award Plan [Member]
Inducement award plan.
Cybersecurity Risk Management, Strategy, and Governance [Table]
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Summary of Basic and Diluted Net Loss per Share Attributable to Common Stockholders
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract]
Nontaxable nondeductible items:
Proceeds from Issuance of Preferred Stock and Preference Stock
Net proceeds from issuance of preferred stock allocated to warrants
Earnings Per Share, Basic, Total
Net loss per share attributable to common stockholders-basic
Net loss per share attributable to common stockholders-basic
Net loss per share attributable to common stockholders- basic
Executive Chair [Member]
Executive Chair.
Executive Chair
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Shares, Outstanding December 31, 2024
Shares, Outstanding at December 31, 2025
Gain (Loss) on Disposition of Property Plant Equipment, Excluding Oil and Gas Property and Timber Property
Gain on sale of property and equipment
Liabilities, Current
Total current liabilities
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Percentage of common shares increase automatically in each year.
Percentage Of Common Shares Increase Automatically In Each Year
Percentage of common shares increase automatically in each year
Exercise price
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price
Domestic Tax Jurisdiction [Member]
U.S. federal jurisdiction
Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract]
Tax credits, percentage:
Financing costs [Member]
Financing costs.
Financing Costs
Gross proceeds from issuance of common stock.
Gross Proceeds From Issuance Of Common stock
Gross proceeds from issuance of common stock
Milestone Achievements
Milestone Achievements [Member]
Milestone achievements.
Milestone
Accounting Standards Update [Axis]
Equity, Attributable to Parent [Abstract]
Stockholders' (deficit) equity:
Entity Small Business
Entity Small Business
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock-based compensation
Accounting Standards Update 2016-02 [Member]
ASC 842
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Shares, Cancelled
Proceeds from initial public offering, net of underwriting discount
Net proceeds from initial public offering
Proceeds from issuance initial public offering, net
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Aggregate intrinsic value of stock options exercised
Waltham Lease
Waltham Lease [Member]
Waltham lease.
Expected Sublease Rent Increases
Discounted Cash Flow Technique Expected Sublease Rent Increases
Discounted cash flow technique expected sublease rent increases.
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation Expense
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Lease Contractual Term [Axis]
Option to Exercise Stock Warrants
Option to Exercise Stock Warrants [Member]
Option to exercise stock warrants.
Leases [Abstract]
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Amendment Flag
Amendment Flag
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Income tax computed at federal statutory tax rate
Issue Date
Class of Warrant or Right, Date from which Warrants or Rights Exercisable
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of warrants issued to purchase common stock
Warrants to purchase common shares
Chief Executive Officer [Member]
Chief Executive Officer
Earnings Per Share, Policy [Policy Text Block]
Net Loss per Share
Immaterial Error Correction
Liabilities and Equity [Abstract]
Liabilities and Stockholders' (Deficit) Equity
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities
Employee related costs [Member]
Employee related costs.
Employee Related Costs
Common Stock [Member]
Common Stock
Cybersecurity Risk Role of Management [Text Block]
Weighted Average Exercise Price, Granted
Exercise price per share, granted
Average per share price
Lessee, Operating Lease, Liability, to be Paid, Year Three
2028
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Secured Debt
Secured debt obligations
Secured Debt, Total
Deferred tax assets operating lease liabilities.
Deferred Tax Assets Operating Lease Liabilities
Operating lease liabilities
Entity Address, Address Line One
Entity Address, Address Line One
Deferred Tax Liabilities, Gross
Total deferred tax liabilities
Deferred Tax Liabilities, Gross, Total
Schedule of Fair Value of Stock Option Estimated on Date of Grant Using Black-Scholes Option-Pricing Model or Monte Carlo Simulation in Case of Options Granted to Certain Executive Officers
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Number of Warrants Issued
Class of Warrant or Right, Issued
Class of warrant or right, issued.
Fair Value Hierarchy and NAV [Axis]
Income Tax, Policy [Policy Text Block]
Income Taxes
Twenty thousand twenty employee stock purchase plan.
Twenty Thousand Twenty Employee Stock Purchase Plan [Member]
2020 ESPP
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Stockholders' Equity Note, Redeemable Preferred Stock, Issue, Policy [Policy Text Block]
Classification and Accretion of Redeemable Convertible Preferred Shares
Statement of Financial Position Location, Balance [Axis]
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Deferred Tax Assets, Gross
Total gross deferred tax assets
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Net proceeds from issuance of preferred stock allocated to warrants, net of issuance costs
Proceeds From Issuance Of Preferred Stock And Preference Stock, Net Of Issuance Costs
Proceeds from issuance of capital stock, net of issuance costs.
Class of Warrant or Right [Axis]
Document Type
Document Type
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Short-Term Investments [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Debt Securities, Available-for-Sale [Table Text Block]
Schedule of Fair Value of Available-for-sale Investments by Type of Security
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Restructuring Reserve, Current
Restructuring liability
Accrued Research and Development Expenses
Accrued Research and Development Expenses [Policy Text Block]
Accrued research and development expenses.
Valuation Approach and Technique [Axis]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net (decrease) increase in cash, cash equivalents and restricted cash
Subsequent Event Type [Domain]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Potentially dilutive securities excluded from calculation of diluted net loss per share
Loss on impairment of long-lived assets
Loss on impairment of long-lived research and development assets
Impairment of property and equipment
Common Stock, Par or Stated Value Per Share
Common stock par value
Accounting Standards Update [Domain]
Net proceeds from sale of warrants
Proceeds from Issuance of Warrants
Aggregate gross proceeds from issuance of warrants
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Outstanding, Weighted Average Remaining Contractual Life (in years)
Document Financial Statement Error Correction [Flag]
Schedule of Costs of Retirement Plans [Table Text Block]
Schedule of Matching contribution expenses
Other Restructuring Costs
Other costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercise of common stock options, Shares
Shares, Exercised
Stock options exercised
Concentrations of credit risk and off-balance sheet risk.
Concentrations Of Credit Risk And Off Balance Sheet Risk Policy [Text Block]
Concentrations Of Credit Risk And Off Balance Sheet Risk
Asset Impairment Charges [Text Block]
Impairment of Right of Use Assets
Payments for Legal Settlements
Remaining liability paid to the contract manufacture
Remaining liability paid of Stipulation of Dismissal with prejudice to the former CMO
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Current Fiscal Year End Date
Current Fiscal Year End Date
Error Correction, Type [Axis]
Post-milestone.
Post-Milestone [Member]
Post-Milestone
Restricted Cash and Cash Equivalents [Axis]
Restricted Cash and Cash Equivalents
Entity Address, State or Province
Entity Address, State or Province
Restricted stock units outstanding, Ending Balance
Restricted stock units outstanding, Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Expiration Date, Warrants issued
Warrants And Rights Issued, Maturity Date
Warrants And Rights Issued, Maturity Date
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding
Preferred stock shares outstanding
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Unrealized Gains
Net accumulated unrealized gains
Research and Development Expense, Policy [Policy Text Block]
Research and Development Costs
Purchase Agreement
Securities Purchase Agreement [Member]
Securities Purchase Agreement.
Common Stock, Capital Shares Reserved for Future Issuance
Shares of common stock reserved for future issuances
Class of Warrant or Right [Domain]
Impairment of the right-of-use assets
Impairment Of the Right-Of-Use Assets
Impairment Of the Right-Of-Use Assets
Net proceeds after deducting issuance costs
Net Proceeds After Deducting Issuance Costs
Net proceeds after deducting issuance costs.
Clinical related costs [Member]
Clinical related costs.
Clinical Related Costs
Domestic state and local taxes, net of federal effect
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of Stock-Based Compensation Expense
Finance Lease, Liability, Statement of Financial Position [Extensible Enumeration]
Finance Lease, Liability, Statement of Financial Position [Extensible Enumeration]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Other
Stock Issued During Period, Value, Stock Options Exercised
Exercise of common stock options
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Accrued Expenses and Other Current Liabilities
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Deferred Tax Assets and Liabilities
Warrant Two
Warrant Two [Member]
Warrant two.
U.S. Government Agency and foreign national bank securities
U.S. Government Agency and Foreign National Bank Securities [Member]
U.S. Government agency and foreign national bank securities.
Collaborative Arrangement Disclosure [Text Block]
Collaboration Agreement
Office and laboratory.
Office And Laboratory [Member]
Office and Laboratory
Performance Shares [Member]
Performance-Based Stock Awards
Nature of Expense [Axis]
Gross proceeds from private placement
Gross Proceeds From Issuance Of Private Placement
Gross proceeds from issuance of private placement.
Subsequent Event [Member]
Subsequent Events
Deferred Revenue, Current
Deferred revenue
Deferred Revenue, Current, Total
Property, Plant and Equipment [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Increase in Shares available for grant
Deferred Tax Assets, Tax Credit Carryforwards, Research
Deferred Tax Assets, Tax Credit Carryforwards, Research
Antidilutive Securities [Axis]
Antidilutive Securities
Subsidiary or Equity Method Investee [Line Items]
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Aggregate Intrinsic Value, Vested and expected to vest at December 31, 2024
Patent Costs
Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block]
Asset Impairment Charges [Abstract]
State and Local Jurisdiction [Member]
State jurisdiction
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income, Net of Tax
Cash and Cash Equivalents [Domain]
Cash and Cash Equivalents
Lessee, Operating Lease, Option to Extend
Preferred Stock, Value, Issued
Preferred stock, $0.001 par value; 10,000,000 shares authorized at December 31, 2025 and 2024; no shares issued and outstanding at December 31, 2025 and 2024
Maria Palasis Ph D [Member]
Maria Palasis Ph D.
Maria Palasis, Ph.D
Accounting Policies [Line Items]
Accounting Policies [Line Items]
Accounting Policies.
Minimum [Member]
Minimum
Weighted Average Grant Date Fair Value, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Financial Instrument [Axis]
Assets, Current [Abstract]
Current assets:
IRC 382.
I R C 382 Member
IRC 382
Amount available for future sale
Proceeds from stock issuance available for future sale
Proceeds from stock issuance available for future sale.
Fair Value, Inputs, Level 3 [Member]
Segment Reporting [Abstract]
Cash Provided by Financing Activity
Cash provided by financing activity.
Fund raised for operations
Interim Period, Costs Not Allocable [Domain]
Liabilities, Current [Abstract]
Current liabilities:
Decrease in Common Stock for Rounding Down of Fractional Shares To Reflect Reverse Stock Split
Decrease in common stock for rounding down of fractional shares to reflect reverse stock split.
Decrease in common stock for rounding down of fractional shares to reflect the 1-for -50 reverse stock split
Decrease in common stock for rounding down of fractional shares to reflect the 1-for -50 reverse stock split
Restructuring and Other Related Charges
Restructuring and Related Activities Disclosure [Text Block]
Pre-funded warrants exercised
Warrants Exercised
Warrants exercised.
Number of warrants exercised
Weighted Average Exercise Price of Warrants Exercised
Class of Warrant or Right, Exercise Price of Warrants or Rights Exercised
Class of warrant or right, exercise price of warrants or rights exercised.
Development activities performance obligation.
Development Activities Performance Obligation
Development activities performance obligation
Shares, Outstanding
Balance, Shares
Balance, Shares
Operating Loss Carryforwards
Operating loss carryforwards
Other Income
Other income
Two Thousand Twenty Four PSUs [Member]
Two thousand twenty four PSUs.
2024 PSUs
Commitments and Contingencies
Commitments and contingencies (Note 17)
Lessee, Leases [Policy Text Block]
Leases
Number of shares Underlying Warrants Exercisable
Class Of Warrant Or Right Outstanding Exercisable
Class Of warrant or right outstanding exercisable.
Accumulated Depreciation Related to Loss on Impairment of Property and Equipment
Accumulated depreciation related to loss on impairment of property and equipment.
Accumulated depreciation related to loss on impairment of property and equipment
SEC Schedule, 12-09, Valuation Allowances and Reserves [Domain]
Weighted Average Grant Date Fair Value, Ending Balance
Weighted Average Grant Date Fair Value, Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Future milestone payments receivable
Future Milestone Payments Receivable Upon Achievement Of Specified Development Regulatory And Commercialization
Future milestone payments receivable upon achievement of specified development, regulatory and commercialization.
Organization and basis of presentation.
Organization And Basis Of Presentation [Line Items]
Organization And Basis Of Presentation [Line Items]
General and Administrative Expense [Member]
General and Administrative
Operating Lease, Liability
Present value of operating lease liability
Lease liabilities
Other Assets Included In Accounts Payable And Other Current Liabilities
Other assets included in accounts payable and other current liabilities.
Other assets included in accounts payable and other current liabilities
Auditor Firm ID
Auditor Firm ID
Stockholders' Equity, Reverse Stock Split
Reverse stock split of issued and outstanding common stock
Reverse stock split
Third-party research and development expenses current.
Third Party Research And Development Expenses Current
Third-party research and development expenses
Issuance of Common Stock under ESPP
Issuance of common stock under ESPP.
Issuance of common stock under ESPP
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Changes in valuation allowances, percentage
Changes in valuation allowances, percentage
Property and equipment purchases included in accounts payable and accrued expenses
Capital Expenditures Incurred but Not yet Paid
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Lease Contractual Term [Domain]
Twenty thousand twenty incentive award plan.
Twenty Thousand Twenty Incentive Award Plan [Member]
2020 Plan
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted-average common shares outstanding-basic
Weighted-average common shares outstanding-basic
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable at December 31, 2024
Segment Reporting, Expense Information Used by CODM, Description
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Effective Income Tax Rate Reconciliation
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Stock Issued During Period, Shares, Reverse Stock Splits
Decrease in common stock for rounding down of fractional shares to reflect the 1-for -50 reverse stock split
Purchase Warrants [Member]
Purchase warrants.
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Proceeds from Issuance of Private Placement
Net proceeds from private placement
Combined performance obligation.
Combined Performance Obligation [Member]
Combined Performance Obligation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition, Total
Issuance of Stock Debt Securities Warrants and Units Net of Issuance Cost
Issuance of stock debt securities warrants and units net of issuance cost.
Issuance of stock, debt securities, warrants and units, net of issuance cost
Deferred Tax Asset, In-Process Research and Development
Research and development credits
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Changes in valuation allowances
Equity, Attributable to Parent
Balance
Balance
Total stockholders' (deficit) equity
Stockholders' equity
Payments to Acquire Investments, Total
Payments to Acquire Investments
Purchase of investments
Purchase of investments
Purchases of short-term investments
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Lessee, Operating Lease, Existence of Option to Extend [true false]
Statement of Stockholders' Equity [Abstract]
Series C Preferred Stock [Member]
Series C Preferred Stock
Type of Restructuring [Domain]
Valuation Approach and Technique [Domain]
Issuance of common stock and pre-funded warrants, net of issuance costs
Issuance of common stock and pre-fundedwarrants, net of issuance costs of $4,244
Stock Issued During Period Value Issuance Of Common Stock And Pre Funded Warrants Net Of Issuance Costs
Stock issued during period value issuance of common stock and pre-funded warrants, net of issuance costs.
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Proceeds From Issuance Of Equity Net
Proceeds From Issuance Of Equity Net.
Proceeds from issuance of equity net
Over-Allotment Option [Member]
Exercise of Underwriters' Option
Leasehold Improvements [Member]
Leasehold Improvements
Fair Value Disclosures [Text Block]
Fair Value Measurements
Schedule of Assumptions Used in Black Scholes Model
Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award [Table Text Block]
Discounted Cash Flow Technique Term
Discounted cash flow technique term.
Term (years)
Warrants and Rights Note Disclosure [Abstract]
Retention Costs [Member]
Retention costs.
Retention Costs
Entity Incorporation, Date of Incorporation
Entity incorporation, date of incorporation
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure of non-cash financing and investing activities:
Private Warrant [Member]
Private warrant.
Accrued Liabilities and Other Liabilities
Accrued expenses and other current liabilities
Total accrued expenses and other current liabilities
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Plan Name [Domain]
Plan Name
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Contract Termination
Contract Termination [Member]
Annual increase in number of shares available for issuance as percentage on outstanding shares of common stock on final day of immediately preceding calendar year.
Annual Increase In Number Of Shares Available For Issuance As Percentage On Outstanding Shares Of Common Stock On Final Day Of Immediately Preceding Calendar Year
Annual increase in number of shares available for issuance as percentage of outstanding shares common stock on final day of immediately preceding fiscal year
Business Description and Basis of Presentation [Text Block]
Organization, Restructuring, Going Concern and Basis of Presentation
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Two thousand twenty four performance option.
PerformanceSharesMember
2024 Performance Option
Certificates of Deposit [Member]
Certificate of Deposits
Number of Warrants Outstanding, Ending Balance
Number of Warrants Outstanding, Beginning Balance
Number of shares Underlying Warrants Outstanding
Class of Warrant or Right, Outstanding
Restructuring Plan [Axis]
Other adjustments
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Class of Warrant or Right [Table]
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Area of Real Estate Property
Area of property
Entity Address, City or Town
Entity Address, City or Town
Deferred Tax Liabilities Operating lease right-of-use assets.
Deferred Tax Liabilities Operating Lease Right Of Use Assets
Operating lease right-of-use assets
Computer Software And Equipment [Member]
Computer Software And Equipment [Member]
Computer Software and Equipment
Security Exchange Name
Security Exchange Name
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Other adjustments, percentage
Total
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Debt Securities, Available-for-Sale, Unrealized Gain (Loss)
Debt Securities, Available-for-Sale, Unrealized Gain (Loss), Total
Unrealized loss on available-for-sale securities
Counterparty Name [Axis]
Net operating losses
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income tax expense
Loss before income tax expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Shares, Vested and expected to vest at December 31, 2025
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Permanent differences
Executive Officer [Member]
Executives
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Beginning Balance
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Ending Balance
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Total
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Statistical Measurement [Domain]
Statistical Measurement
Weighted Average Exercise Price of Warrants Outstanding, Ending Balance
Weighted Average Exercise Price of Warrants Outstanding, Beginning Balance
Exercise Price
Weighted Average Exercise Price of Warrants Outstanding
Warrants exercise price, per share
Assets, Current
Total current assets
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Document Period End Date
Document Period End Date
Reduction of Common Stock Fractional Share
Reduction of common stock fractional share.
Reduction of common stock fractional share
Title and Position [Axis]
Title of Individual
Fair Value Hierarchy and NAV [Domain]
Accrued expenses and other current liabilities disclosure.
Accrued Expenses And Other Current Liabilities Disclosure [Text Block]
Accrued Expenses and Other Current Liabilities
Number of Leased Properties Marketed for Sublease Arrangements
Number of leased properties marketed for sublease arrangements.
Number of leased properties marketed for sublease arrangements
Defined Contribution Plan, Cost
Match cost
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Twenty Twenty Four Restructuring Plan [Member]
Twenty twenty four restructuring plan.
2024 Restructuring Plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Shares, Exercisable at December 31, 2025
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units
Pre-milestone.
Pre-Milestone [Member]
Pre-Milestone
Authorized number of shares remained unchanged
Authorized Number of Shares Remained Unchanged
Authorized number of shares remained unchanged.
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation [Abstract]
Class of Stock [Axis]
Class of Stock
Stock Debt Securities Warrants And Units Issued
Stock, debt securities, warrants and units issued.
Stock, debt securities, warrants and units sold
Compensation and Employee Benefit Plans [Text Block]
Retirement Plan
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Expiration Date
Warrants and Rights Outstanding, Maturity Date
Percentage of aggregate commission
Percentage Of Aggregate Commission
Percentage of aggregate commission.
Liabilities
Total liabilities
Financial Instruments [Domain]
Restructuring and Related Cost, Incurred Cost
Restructuring and other related charges
Equity Method Investments [Policy Text Block]
Short-term Investments
Restructuring Reserve, Accrual Adjustment
Accruals
Restructuring liability
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Restricted cash
Restricted Cash
Restricted Cash, Total
Weighted-average common shares outstanding-diluted
Weighted-average common shares outstanding-diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Number of leases
Number of leases.
Entity File Number
Entity File Number
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized holding income (loss) on short-term investments, net of tax
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent
Other
Other Assets, Total
Other Assets
Other assets
Amended controlled offering sales agreement [Member]
Amended controlled offering sales agreement.
Amended controlled offering sales agreement
Represents the patents cost policy.
Patents Costs Policy [Text Block]
Patents Costs
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Restricted stock units outstanding shares, Forfeited
Restricted stock units outstanding shares, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
US Treasury Securities [Member]
US Treasury Bills
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Shares available for issuance
Number of Operating Segments
Number of operating segment
Sale of Stock [Domain]
Sale of Stock
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount [Abstract]
Number of Warrants Exercised
Number of Warrants Exercised
Class of Warrant or Right, Exercised
Class of warrant or right, exercised.
Deferred Tax Assets, Other
Other
Short-Term Debt, Type [Domain]
Short-term Debt, Type
Effective income tax rate reconciliation ownership change.
Effective Income Tax Rate Reconciliation Ownership Change
Loss of Attributes - IRC 382 Ownership Change
Operating Lease, Expense
Initial base rent
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price, Vested and expected to vest at December 31, 2024
Increase (Decrease) in Restructuring Reserve
Restructuring liability
Upfront payment received
Upfront Payment Received
Upfront payment received.
Restructuring Charges
Restructuring Charges, Total
Restructuring and other related charges
Restructuring charge
Property, Plant and Equipment, Useful Life
Property and equipment, gross
Short-Term Debt, Type [Axis]
Short-term Debt, Type
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Issued Accounting Pronouncements
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Summary of Maturity of Operating Lease Liabilities
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Unit Activity, Including 2024 PSUs
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Other, percentage
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Employee Severance [Member]
Severance Costs
Employee Severance
Summary of weighted average remaining lease terms and discount rate related to operating leases.
Summary Of Weighted Average Remaining Lease Terms And Discount Rate Related To Operating Leases Table [Text Block]
Summary of Weighted-Average Remaining Lease Term and Discount Rate Related to Operating Leases
Proceeds from Issuance of Stock Debt Securities Warrant and Unit
Proceeds from issuance of stock debt securities warrant and unit.
Proceeds from issuance of Stock, debt securities, warrant and unit
Depreciation
Depreciation expense
Depreciation, Total
Common Stock, Shares, Outstanding
Common stock shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Operating Lease, Liability, Current
Operating lease liabilities
Less: Current portion of operating lease liability
Lease liabilities
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Document Transition Report
Deferred Tax Assets, Net
Net deferred taxes
Deferred Tax Assets, Net, Total
Short-Term Investments, Total
Short-Term Investments
Short-term investments
Operating Expenses
Total operating expenses
Off-Balance-Sheet Credit Exposure, Policy [Policy Text Block]
Concentrations Of Credit Risk And Off Balance Sheet Risk
Operating Loss Carryforwards, Limitations on Use
Operating loss carryforwards limitations on use
Development Milestone Achieved
Milestone
Development milestone achieved.
Research and Development Expense
Research and development
Research and Development Expense, Total
Research and development costs
Impairment charge for write-down of property and equipment
Asset Impairment Charges
Asset Impairment Charges, Total
Loss on impairment of property and equipment
Lessee, Operating Leases [Text Block]
Leases
Valuation Technique, Discounted Cash Flow [Member]
Discounted Cash Flow Technique
Statement of Cash Flows [Abstract]
Exercise of pre-funded warrants, Shares
Stock Issued During Period Shares Exercise Of Pre Funded Warrants
Stock issued during period, shares, Exercise of pre-funded warrants.
Issuance of stock, value
Stock Issued During Period, Value, New Issues
Shares issued under ATM, net of issuance costs
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity, Including Incentive Options, Under Plans
Stock and warrants to be issued during period value preferred stock and warrants.
Stock And Wrrants To Be Issued During Period Value Preferred Stock And Warrants
Stock and warrants to be issued during period value preferred stock and warrants
Effective Income Tax Rate Reconciliation Nondeductible Expense Compensation Limit
Effective Income Tax Rate Reconciliation Nondeductible Expense Compensation Limit.
162 (m) compensation limit, percentage
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Stock compensation, percentage
Equity [Text Block]
Preferred and Common Stock
Shares, Issued
Shares issued
Issuance of common stock under ESPP
Computer Equipment [Member]
Computer software and equipment
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss
Net operating losses
Net loss
Aggregate Intrinsic Value, Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Sales Agreement
Sales Agreement [Member]
Sales agreement.
Going concern policy text block.
Going Concern Policy [Text Block]
Going Concern
Operating Lease, Cost
Operating lease cost
Weighted average remaining contractual term
Weighted Average Remaining Contractual Term of Warrants Outstanding
Warrants and Rights Outstanding, Term
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Proceeds From Issuance Of Stock Debt Securities Warrants And Units
Proceeds from issuance of Stock, debt securities, warrants and units.
Proceeds from issuance of Stock, debt securities, warrants and units
162 (m) compensation limit
Income Tax Reconciliation Nondeductible Expense Compensation Limit
Income Tax Reconciliation Nondeductible Expense Compensation Limit.
Assets [Abstract]
Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Construction in Progress [Member]
Construction in Progress
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Restructuring and Related Activities [Abstract]
Document Fiscal Year Focus
Document Fiscal Year Focus
Other Assets [Member]
Other assets
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities:
Retirement Benefits [Abstract]
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Research and Development Expense [Member]
Research and Development
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Short-term Investments
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Maximum contribution employee percentage
Stock Debt Securities Warrants And Units Issuance Costs
Stock debt securities warrants and units issuance costs.
Deferred Revenue, Total
Deferred Revenue
Deferred Revenue
Deferred revenue at beginning
Deferred revenue at ending
Subsidiary or Equity Method Investee, Sale of Stock [Table]
Restructuring Cost and Reserve [Line Items]
Clinical Supply Agreement member.
Clinical Supply Agreement [Member]
Clinical Supply Agreement
Common Stock Warrants
Common Stock Warrants Disclosure [Text Block]
The entire disclosure for common stock warrants.
Proceeds from Stock Options Exercised
Proceeds from exercise of stock options
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Commitment and Contingencies
Discounted Cash Flow Technique Range Of Assumption [Table]
Discounted cash flow technique range of assumption.
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Common stock voting rights, number of votes.
Common Stock Voting Rights Number Of Votes
Number of common stock voting rights
Issuance of common stock upon RSU vesting, shares
Stock Issued During Period Shares Vesting Of Restricted Stock Unit
Stock issued during period shares vesting of restricted stock unit.
Lessee, operating lease, extended lease term.
Lessee Operating Lease Extended Lease Term
Extended lease term
Deferred Debt Issuance Cost, Writeoff
Write-off of deferred financing costs
Gross proceeds under agreement
Sale of Stock, Consideration Received on Transaction
Net Income (Loss) Available to Common Stockholders, Basic
Net loss attributable to common stockholders
Shares of common stock reserved for future issuances.
Shares Of Common Stock Reserved For Future Issuances Table [Text Block]
Schedule of Common Stock Reserved for Future Issuances
Share-Based Payment Arrangement [Abstract]
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Unrecognized expense
Debt Securities, Available-for-Sale [Abstract]
Purchase price of shares as percentage lower of fair market value of common stock.
Purchase Price Of Shares As Percentage Lower Of Fair Market Value Of Common Stock
Purchase price of shares as percentage lower of fair market value of common stock
Sale of Stock [Axis]
Sale of Stock
Aggregate intrinsic Value of Warrants Outstanding, Beginning Balance
Warrants and Rights Outstanding Aggregate Intrinsic Value, Beginning Balance
Warrants and rights outstanding aggregate intrinsic value, beginning balance.
Aggregate intrinsic Value of Warrants Outstanding, Beginning Balance
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash (used in) provided by investing activities
Private Placement
Private Placement [Member]
May Two Thousand Twenty Three Financing [Member]
May two thousand twenty three financing.
May 2023 Financing
Combined performance obligation
Combined Performance Obligation
Combined performance obligation
Title of 12(b) Security
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Stock compensation
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Cancelled
Weighted Average Grant Date Fair Value, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Money Market Funds [Member]
Money Market Funds
Income Tax Disclosure [Text Block]
Income Taxes
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Class of Warrant or Right [Line Items]
Discounted Cash Flow Technique Discount Rate
Discounted cash flow technique discount rate.
Discount Rate
Rule10b51ArrModifiedFlag
Rule10b51ArrModifiedFlag
Rule 10b5-1Arrangement Modified
Cantor Fitzgerald & Co.
Cantor Fitzgerald & Co. [Member]
Cantor Fitzgerald & Co.
Restructuring Plan [Domain]
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities
Property, Plant and Equipment [Table Text Block]
Property Plant And Equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price, Outstanding December 31, 2023
Weighted Average Exercise Price, Outstanding December 31, 2024
Aggregate intrinsic Value of Warrants Exercised
Warrants and Rights Exercised Intrinsic Value
Warrants and rights exercised intrinsic value.
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Accrued expenses and other current liabilities
Prepaid expenses for right-of-use asset included in operating lease liabilities
Prepaid expenses for right-of-use asset included in operating lease liabilities
Prepaid expenses for right-of-use asset included in operating lease liabilities
Measurement Frequency [Domain]
Statement of Income Location, Balance [Axis]
Income Statement Location
Trading Symbol
Trading Symbol
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment and Related Impairment
Annual increase in number of shares available for issuance maximum number of common stock issued.
Annual Increase In Number Of Shares Available For Issuance Maximum Number Of Common Stock Issued
Maximum number of common shares issued
Subsequent Event Type [Axis]
Stock Exchange Stock Trading Description
Stock exchange stock trading description.
Stock exchange stock trading description
Employee-related Liabilities, Current
Payroll and employee related expenses
Employee-related Liabilities, Current, Total
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities:
Expected term
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Fair Value, Recurring [Member]
Entity Ex Transition Period
Entity Ex Transition Period
Lessee, Operating Lease, Liability, to be Paid
Total maturities
Less: Imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research credits, percentage
Other Restructuring [Member]
Other Costs
Equity Components [Axis]
Equity Components
Deferred tax assets capitalized research and experimental expenditures.
Deferred Tax Assets Capitalized Research and Experimental Expenditures
Capitalized research & experimental expenditures
Issuance Of Common Stock Shares Upon Exercise Of Pre Funded Warrants
Issuance of common stock shares upon exercise of pre-funded warrants.
Issuance of common stock upon exercise of pre-funded warrants, Shares
Nonoperating Income (Expense)
Total other income
Equity Component [Domain]
Equity Component
Adjustments to additional paid in capital, sale of common stock and warrants
Adjustments to Additional Paid in Capital Common Stock and Warrants
Adjustments to additional paid in capital common stock and warrants.
Directors or Officers [Member]
Directors or officers.
Deferred Revenue, Noncurrent
Deferred revenue, net of current portion
Deferred Revenue, Noncurrent, Total
Deferred Tax Assets, Deferred Income
Deferred revenue
SEC Schedule, 12-09, Valuation Allowance, Deferred Tax Asset [Member]
Valuation Allowance of Deferred Tax Assets [Member]
Document Annual Report
Document Annual Report
Warrant Three
Warrant Three [Member]
Warrant three.
Stock-based compensation expense recorded as liability
Deferred Compensation Share-Based Arrangements, Liability, Current and Noncurrent
Increase (Decrease) in Other Current Assets
Other assets
Gross proceeds from initial public offering.
Gross Proceeds From Initial Public Offering
Gross proceeds from initial public offering
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Issuance of common stock upon RSU vesting, shares
IPO [Member]
IPO
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of common stock under ESPP
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Stock option expiration period
Error Correction, Type [Domain]
Common Stock, Voting Rights
Common stock, voting rights
Maximum [Member]
Maximum
Performance Obligations
Performance Obligations [Member]
Performance obligations.
Statistical Measurement [Axis]
Statistical Measurement
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercised
Common Stock, Value, Issued
Common stock, $0.001 par value; 200,000,000 shares authorized at December 31, 2025 and 2024; 1,774,882 and 1,310,308 shares issued and outstanding as of December 31, 2025 and 2024, respectively
Non Rule 10b51Arr Modified Flag
Non Rule 10b51Arr Modified Flag.
Non Rule 10b5-1Arrangement Modified
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Stock Options and Restricted Stock Units
Stock Options And Restricted Stock Units [Member]
Stock options and restricted stock units.
Equipment [Member]
Equipment
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Other comprehensive loss:
Number of reduction in workforce employees
Restructuring and Related Cost, Expected Number of Positions Eliminated
ATM
At The Market [Member]
At the market.
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Domestic state and local taxes, net of federal effect, percentage
Open sales agreement (2021 ATM) [Member]
Open Sales Agreement2021 A T M [Member]
2021 ATM Agreement
Entity Public Float
Entity Public Float
Volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Preferred Stock, Shares Authorized
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Temporary Equity, Accretion to Redemption Value, Adjustment
Accretion of redeemable convertible preferred stock
Shelf registration statement on Form S3 [Member]
Shelf registration statement on Form S-3.
Shelf Registration Statement on Form S-3
Accounting Policies [Table]
Accounting Policies [Table]
Accounting Policies.
Employee Stock [Member]
Employee stock purchase plan
Estimated Offering Costs
Estimated offering costs.
Estimated offering costs
Entity Registrant Name
Entity Registrant Name
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Unrealized Losses
Net accumulated unrealized losses
Entity Voluntary Filers
Entity Voluntary Filers
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Income Tax Expense (Benefit)
Income Tax Expense (Benefit)
Income tax expense
Deferred tax assets, valuation allowance income tax expense (benefit)
Total
Debt Securities, Available-for-Sale, Unrealized Loss
Unrealized loss on available-for-sale securities
Measurement Frequency [Axis]
Controlled Equity Offering Sales Agreement
Controlled Equity Offering Sales Agreement [Member]
Controlled Equity Offering Sales Agreement.
Net proceeds
Proceeds from Issuance of Common Stock
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Issuance of stock, debt securities, warrants and units, net of issuance costs
Issuance Of Stock Debt Securities Warrants And Units Net Of Issuance Costs
Issuance of stock debt securities warrants and units net of issuance costs.
Compensation Related Costs, Policy [Policy Text Block]
Accounting for Stock-Based Compensation
Deferred Revenue, Revenue Recognized
Revenue recognized
Revenue recognized
COVID-19 Pandemic and CARES Act.
C O V I D19 Pandemic And C A R E S Act Policy [Text Block]
COVID-19 Pandemic and CARES Act
Payments for Restructuring
Cash Payments
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Restricted stock units granted
Restricted stock units outstanding shares, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Assets
Total assets
Pre Funded Warrants
Pre Funded Warrants [Member]
Pre-funded warrants.
Pre-Funded Warrants
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Exercisable, Weighted Average Remaining Contractual Life (in years)
Income Statement [Abstract]
Restructuring Cost [Table]
Warrants and Rights Outstanding Aggregate Intrinsic Value, Ending Balance
Warrants and rights outstanding aggregate intrinsic value, ending balance.
Aggregate intrinsic Value of Warrants Outstanding, Ending Balance
Aggregate intrinsic Value of Warrants Outstanding, Ending Balance
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value of Financial Instruments
Stock Issued During Period, Shares, New Issues
Issuance of common stock
Shares issued under ATM, net of issuance costs, Shares
Lease, Cost [Abstract]
Lease Cost:
Restricted stock units outstanding shares, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Earnings Per Share, Diluted, Total
Net loss per share attributable to common stockholders-diluted
Net loss per share attributable to common stockholders-diluted
Net loss per share attributable to common stockholders-diluted
Significant suppliers policy.
Significant Suppliers Policy [Text Block]
Significant Suppliers
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Summary of Revenue Significant Expenses and Net Loss for Segment
Title and Position [Domain]
Title of Individual
Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration]
City Area Code
City Area Code
Legal Settlement Adjustment [Member]
Legal settlement adjustment.
Legal Settlement
Error Correction
Error Correction, Other [Member]
Auditor Name
June 2025 Financing
June Two Thousand Twenty Five Financing [Member]
June two thousand twenty five financing.
Impairment Of Right Of Use Asset [Member]
Impairment of right of use asset.
Impairment Of Right Of Use Asset
Counterparty Name [Domain]
Research credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Variable Lease, Cost
Variable lease cost
Operating Lease, Weighted Average Remaining Lease Term
Weighted-average remaining lease term (in years)
Segment Reporting Information [Line Items]
Stockholders' Equity Note, Stock Split, Conversion Ratio
Reverse stock split, ratio
Lease, Cost
Total lease cost
Professional, consulting and public company costs [Member]
Professional, consulting and public company costs.
Professional, Consulting and Public Company Costs
Letter of Credit [Member]
Letter of Credit
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Property, Plant and Equipment, Net
Property and equipment, net
Property and equipment, net
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total
Issuance of common stock upon RSU vesting
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, cash equivalents and restricted cash, beginning of period
Cash, cash equivalents and restricted cash, end of period
Operating Income (Loss)
Loss from operations
Retained Earnings [Member]
Accumulated Deficit
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense, Total
Payments of Stock Issuance Costs
Payments Of Stock Issuance Costs
Payment of deferred offering costs
Warrants And Rights Issued, Weighted Average Remaining Contractual Term
Weighted average remaining contractual term of prefunded and common warrants issued, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.
Weighted Average Remaining Contractual Term of Warrants Issued
Restructuring and Related Cost, Number of Positions Eliminated
Number of employees reduced
Warrant One
Warrant One [Member]
Warrant one.
Facilities, support costs and depreciation [Member]
Facilities, support costs and depreciation.
Facilities, Support Costs and Depreciation
Operating Lease, Weighted Average Discount Rate, Percent
Weighted-average discount rate
Operating Lease, Liability, Noncurrent
Operating lease liabilities, net of current portion
Fair Value, Inputs, Level 1 [Member]
Class of Stock [Line Items]
Class Of Stock [Line Items]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Lease, Cost [Table Text Block]
Components of Lease Cost
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract]
Nontaxable nondeductible items, percentage:
Auditor Location
Document Document And Entity Information Abstract
Document Document And Entity Information [Abstract]
Document - Document And Entity Information [Abstract]
Summary of Warrants Outstanding and Exercisable and Warrant Activity
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Watertown Lease
Watertown Lease [Member]
Watertown lease.
Nonoperating Income (Expense) [Abstract]
Other income:
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of Potentially Dilutive Securities Excluded from Calculation of Diluted Net Loss per Share
Revenue Recognition, Milestone Method [Table Text Block]
Summary of Change in the Transaction Price
Corporate Debt Securities [Member]
Corporate Debt Securities
Income Tax Jurisdiction [Domain]
Entity Interactive Data Current
Entity Interactive Data Current
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Statement of Income Location, Balance [Domain]
Income Statement Location
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities:
Furniture and Fixtures [Member]
Office Furniture and Fixtures
Convertible Preferred Stock, Shares Issued upon Conversion
Preferred stock converted into common stock
Accretion (Amortization) of Discounts and Premiums, Investments
Net amortization of discount on short-term investments
Waltham Sublease
Waltham Sublease [Member]
Waltham sublease.
Unrecognized Tax Benefits, Income Tax Penalties Accrued
Unrecognized tax benefits income tax penalties accrued
Upfront payment recognition in future periods to settlement of obligation
Upfront Payment Recognition In Future Periods To Settlement Of Obligation
Upfront payment recognition in future periods to settlement of obligation.
Total
Stock Issued During Period, Shares, Issued for Services
Vested share of common stock
Option Indexed to Issuer's Equity, Type [Domain]
Option Indexed to Issuer's Equity, Type
Market-based condition awards.
Market-Based Condition Awards [Member]
Market-Based Condition Awards
Entity Tax Identification Number
Entity Tax Identification Number
Fair value of common stock
Share Price
Stock issued during period, value, exercise of common stock warrants
Stock issued during period, value, exercise of common stock warrants.
Issuance of common stock upon exercise of common stock warrants
Maturity of short-term investments
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance or Sale of Equity, Total
Issuance of equity securities
Local Phone Number
Local Phone Number
Schedule of accrued expenses and other current liabilities.
Schedule Of Accrued Expenses And Other Current Liabilities Table [Text Block]
Schedule of Accrued Expenses and Other Current Liabilities
Debt Securities, Available-for-Sale, Unrealized Gain
Unrealized gain on available-for-sale securities
Other Liabilities, Current
Other
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Auditor Opinion [Text Block]
Percentage of annual rent increment
Percentage Of Annual Rent Increment
Percentage of annual rent increment.
Weighted average exercise price
Weighted Average Exercise Price of Warrants Issued
Class of Warrant or Right, Exercise Price of Warrants or Rights Issued
Class of warrant or right, exercise price of warrants or rights issued.
Research Development General and Administrative Expense
Research development general and administrative expense.
Research development general and administrative costs
Deferred tax assets valuation allowance income tax expense (benefit).
Deferred Tax Assets Valuation Allowance Income Tax Expense (Benefit)
Deferred tax assets, valuation allowance income tax expense (benefit)
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Issuance cost
Increase decrease in operating lease right-of-use asset.
Increase Decrease In Operating Lease Right Of Use Asset
Operating lease right-of-use assets
Accounting Policies [Abstract]
Deferred Revenue, by Arrangement, Disclosure [Table Text Block]
Schedule of Revenue Recognized Related to Each of the Performance Obligations and the Remaining Deferred Revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Collaboration revenue
Common Warrants
Common Warrants [Member]
Common warrants.
Lessee, Operating Lease, Liability, to be Paid, Year Four
2029
Class of Stock [Domain]
Class of Stock
Deferred Revenue, Description
Deferred revenue, description
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Number of shares available for future issuance
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unvested stock options expected to be recognized over a weighted-average period
Period of recognition (years)
Office Equipment [Member]
Office furniture and fixtures
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Company match percentage
Stock Issuance Costs Available for Future Sale
Stock issuance costs available for future sale.
Amount available for future sale
Stock, Class of Stock [Table]
Schedule Of Stock By Class [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Vested and expected to vest, Weighted Average Remaining Contractual Life (in years)
Exercise of pre-funded warrants
Stock Issued During Period Values Exercise Of Pre Funded Warrants
Stock issued during period, values, exercise of pre-funded warrants.
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name