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Your Vote Counts! LYRA THERAPEUTICS, INC. 2023 Annual Meeting Vote by June 12, 2023 11:59 PM EDT LYRA THERAPEUTICS, INC. 480 ARSENAL WAY WATERTOWN, MASSACHUSETTS 02472 V14059-P90659 You invested in LYRA THERAPEUTICS, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the stockholder meeting to be held on June 13, 2023. Get informed before you vote View the Notice and Proxy Statement and Form 10-K online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 30, 2023. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. For complete information and to vote, visit Control # Vote Virtually at the Meeting* Date: June 13, 2023 Time: 8:30 AM EDT Smartphone users Point your camera here and vote without entering a control number Meeting to be held virtually at: *Please check the meeting materials for any special requirements for meeting attendance. V1.2 


Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items 1. Election of Class III Directors to serve until the 2026 Annual Meeting of Stockholders, and until their respective successors shall have been duly elected and qualified. Nominees: For 01) Maria Palasis, Ph.D. 02) W. Bradford Smith 03) James R. Tobin 2. To ratify the appointment of BDO USA, LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2023. For NOTE: Such other business as may properly come before the Annual Meeting or any continuation, postponement or adjournment thereof. Prefer to receive an email instead? While voting on, be sure to click “Delivery Settings”. V14060-P90659