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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(AMENDMENT NO. 1)*
Lyra Therapeutics, Inc.
(Name of Issuer)
Common Stock, $0.001 par value per share
(Title of Class of Securities)
55234L105
(CUSIP Number)
December 31, 2022
(Date of Event which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
[ ] Rule 13d-1(b)
[ X ] Rule 13d-1(c)
[ ] Rule 13d-1(d)
* The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section
of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).
CUSIP No. 55234L105
13G
Page 2 of 7 Pages
1.
NAMES OF REPORTING PERSONS OR
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Pura Vida Investments, LLC
2.
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(see instructions)
(a) [ ]
(b) [ x ]
3.
SEC USE ONLY
4.
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.
SOLE VOTING POWER
0
6.
SHARED VOTING POWER
2,157,298*
7.
SOLE DISPOSITIVE POWER
0
8.
SHARED DISPOSITIVE POWER
2,157,298*
9.
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,157,298*
10.
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(see instructions) [ ]
11.
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
6.78%**
12.
TYPE OF REPORTING PERSON (see instructions)
IA
CUSIP No. 55234L105
13G
Page 3 of 7 Pages
1.
NAMES OF REPORTING PERSONS OR
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Efrem Kamen
2.
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(see instructions)
(a) [ ]
(b) [ x ]
3.
SEC USE ONLY
4.
CITIZENSHIP OR PLACE OF ORGANIZATION
USA
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.
SOLE VOTING POWER
0
6.
SHARED VOTING POWER
2,157,298*
7.
SOLE DISPOSITIVE POWER
0
8.
SHARED DISPOSITIVE POWER
2,157,298*
9.
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,157,298*
10.
CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(see instructions) [ ]
11.
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
6.78%**
12.
TYPE OF REPORTING PERSON (see instructions)
IN, HC
CUSIP No. 55234L105
13G
Page 4 of 7 Pages
Item 1.
(a)
Name of Issuer
Lyra Therapeutics, Inc.
(b)
Address of Issuers Principal Executive Offices
480 Arsenal Way, Watertown, MA 02472
Item 2.
(a)
Name of Person Filing
Pura Vida Investments, LLC
Efrem Kamen
(collectively, the "Filers").
(b)
The address of the principal place of the Filers is located at:
Pura Vida Investments, LLC 512 West 22nd Street, 7th Floor, New York, NY 10011
(c)
For citizenship of Filers, see Item 4 of the cover sheet for each Filer.
(d)
Title of Class of Securities
Common Stock, $0.001 par value per share
(e)
CUSIP Number
55234L105
Item 3. If this statement is filed pursuant to Rules 13d-1(b) or 240.13d-2(b)
or (c), check whether the person filing is a:
(a)
[ ]
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
(b)
[ ]
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
(c)
[ ]
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
(d)
[ ]
Investment company registered under section 8 of the Investment Company Act of
1940 (15 U.S.C. 80a-8).
(e)
[x]
An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);
(f)
[ ]
An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)
(ii)(F);
(g)
[ ]
A parent holding company or control person in accordance with Rule 13d-1(b)(1)
(ii)(G);
(h)
[ ]
A savings associations as defined in Section 3(b) of the Federal Deposit
Insurance Act (12 U.S.C. 1813);
(i)
[ ]
A church plan that is excluded from the definition of an investment company
under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
[ ]
Group, in accordance with Rule 13d-1(b)(1)(ii)(J).
CUSIP No. 55234L105
13G
Page 5 of 7 Pages
Item 4. Ownership.
(a) Amount beneficially owned: Pura Vida Investments LLC 2,157,298* shares
Efrem Kamen 2,157,298* shares
(b) Percent of class: Pura Vida Investments LLC 6.78%** Efrem Kamen 6.78%**
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote 0
(ii) Shared power to vote or to direct the vote Pura Vida Investments LLC
2,157,298* shares Efrem Kamen 2,157,298* shares
(iii) Sole power to dispose or to direct the disposition of 0 (iv) Shared
power to dispose or to direct the disposition of Pura Vida Investments,
LLC 2,157,298* shares Efrem Kamen 2,157,298* shares
*Shares reported herein are owned by Pura Vida Master Fund, Ltd. (the "Pura
Vida Master Fund"), Pura Vida X Fund LP (the "Pura Vida X Fund) and certain
separately managed accounts (the "Managed Accounts," collectively the "Client
Accounts"). Pura Vida Investments, LLC ("PVI") serves as the investment
manager or sub-adviser to the Client Accounts. Efrem Kamen serves as the
Managing Member of PVI. Efrem Kamen serves as the managing member of PVI.
By virtue of these relationships, the Reporting Persons may be deemed to have
shared voting and dispositive power with respect to the Shares owned directly
by the Pura Vida Master Fund and the Managed Accounts. This report shall not
be deemed an admission that the Reporting Persons are beneficial owners of the
Shares for purposes of Section 13 of the Securities Exchange Act of 1934, as
amended, or for any other purpose. Each of the Reporting Persons disclaims
beneficial ownership of the Shares reported herein except to the extent of
the Reporting Persons pecuniary interest therein.
**The percentages herein are calculated based upon 31,827,008 shares of Common
Stock of the Issuer outstanding per the Issuers Form 10-Q filed with the
Securities and Exchange Commission on November 1, 2022.
Item 5. Ownership of Five Percent or Less of a Class.
N/A
Item 6. Ownership of More than Five Percent on Behalf of Another Person.
N/A
Item 7. Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on By the Parent Holding Company.
N/A
CUSIP No. 55234L105
13G
Page 6 of 7 Pages
Item 8. Identification and Classification of Members of the Group.
N/A
Item 9. Notice of Dissolution of Group.
N/A
Item 10. Certification.
By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.
Exhibits.
Exhibit A Joint Filing Agreement.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.
Dated: February 14, 2023
Pura Vida Investments, LLC
By: /s/ Efrem Kamen, Managing Member
CUSIP No. 55234L105
13G
Page 7 of 7 Pages
EXHIBIT A
AGREEMENT REGARDING JOINT FILING
OF STATEMENT ON SCHEDULE 13D OR 13G
The undersigned hereby consent and agree to file a joint statement on Schedule
13G under the Securities Exchange Act of 1934, as amended, with respect to the
Pura Vida Investments, LLC. beneficially owned by them, together with any or
all amendments thereto, when and if appropriate. The parties hereto further
consent this Statement pursuant to Rule 13d-1(k)(1)(iii) as an exhibit to
Schedule 13G, thereby incorporating the same into such Schedule 13G.
Dated: February 14, 2023
Pura Vida Investments, LLC
By: /s/ Efrem Kamen, Managing Member